Abstract
Polyalthia is one of the largest genera in the Annonaceae family, and has been widely used in folk medicine for the treatment of rheumatic fever, gastrointestinal ulcer, and generalized body pain. The present investigation reports on the extraction by hydrodistillation and the composition of the essential oils of four Polyalthia species (P. sumatrana, P. stenopetalla, P. cauliflora, and P. rumphii) growing in Malaysia. The chemical composition of these essential oils was determined by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The multivariate analysis was determined using principal component analysis (PCA) and hierarchical clustering analysis (HCA) methods. The results revealed that the studied essential oils are made up principally of bicyclogermacrene (18.8%), cis-calamenene (14.6%) and β-elemene (11.9%) for P. sumatrana; α-cadinol (13.0%) and δ-cadinene (10.2%) for P. stenopetalla; δ-elemene (38.1%) and β-cubebene (33.1%) for P. cauliflora; and finally germacrene D (33.3%) and bicyclogermacrene for P. rumphii. PCA score and HCA plots revealed that the essential oils were classified into three separated clusters of P. cauliflora (Cluster I), P. sumatrana (Cluster II), and P. stenopetalla, and P. rumphii (Cluster III) based on their characteristic chemical compositions. Our findings demonstrate that the essential oil could be useful for the characterization, pharmaceutical, and therapeutic applications of Polyalthia essential oil.
Acknowledgments
The authors would like to thank the Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris (UPSI) for research facilities.
Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
References
1. Nielsen, I. Flowers of Annonaceae: morphology, classification and evolution. Nord J Bot 1993;13:500. https://doi.org/10.1111/j.1756-1051.1993.tb00089.x.Search in Google Scholar
2. International Plant Names Index, 2012. Retrieved on 25 October 2019 Available from: https://www.ipni.org/.Search in Google Scholar
3. Johnson, DM, Murray, NA. Four new species of Polyalthia (Annonaceae) from Borneo and their relationship to Polyalthia insignis. Contrib Univ Mich Herb 1999;22:95–104.Search in Google Scholar
4. Bakker, ME. Annonaceae: Genera worldwide. Expert Center for Taxonomic Identification. Amsterdam: University of Amsterdam; 2000.Search in Google Scholar
5. Li, BT, Gilbert, MG. Polyalthia Blume, Annonaceae, Flora of China. Beijing: Science Press; 2011.Search in Google Scholar
6. Wu, YC, Duh, CY, Wang, SK, Chen, KS, Yang, TH. Two new natural azafluorene alkaloids and a cytotoxic aporphine alkaloid from Polyalthia longifolia. J Nat Prod 1990;53:1327. https://doi.org/10.1021/np50071a028.Search in Google Scholar
7. Wu, YC. Azafluorene and aporphine alkaloids from Polyalthia longifolia. Heterocycles 1989;29:463. https://doi.org/10.3987/com-89-4768.Search in Google Scholar
8. Katkar, KV, Suthar, AC, Chauhan, VS. The chemistry, pharmacologic, and therapeutic applications of Polyalthia longifolia. Pharmacogn Rev 2010;4:62–8. https://doi.org/10.4103/0973-7847.65329.Search in Google Scholar
9. Salleh, WMNHW, Kamil, F, Ahmad, F, Sirat, HM. Antioxidant and anti-inflammatory activities of essential oil and extracts of Piper miniatum. Nat Prod Commun 2015;10:2005–8. https://doi.org/10.1177/1934578X1501001151.Search in Google Scholar
10. Salleh, WMNHW, Ahmad, F, Khong, HY. Antioxidant and anticholinesterase activities of essential oils of Cinnamomum griffithii and C. macrocarpum. Nat Prod Commun 2015;10:1465–8. https://doi.org/10.1177/1934578x1501000838.Search in Google Scholar
11. Azhar, MAM, Salleh, WMNHW, Khamis, S. Essential oil composition of three Cryptocarya species from Malaysia. Z Naturforsch C Biosci 2020; in press. https://doi.org/10.1515/znc-2020-0079.Search in Google Scholar
12. Salleh, WMNHW, Khamis, S, Rahman, MNA, Nafiah, MA. Chemical composition and biological activities of Dipterocarpus cornutus Dyer essential oil. Z Naturforsch C Biosci 2020;75:171–5. https://doi.org/10.1515/znc-2020-0028.Search in Google Scholar
13. Burkill, IH. A Dictionary of Economic Pproducts of the Malay Peninsula. Kuala Lumpur, Malaysia: Ministry of Agriculture and Co-operative; 1966.Search in Google Scholar
14. Burkill, IH, Haniff, M. Malay village medicine. The Garden’s Bulletin Straits Settlement 1930.Search in Google Scholar
15. Kamaruddin, NIM, Ali, NAM, Safian, MF, Ariffin, ZZ. Chemical constituents and in vitro antimicrobial activity of Polyalthia stenopetala essential oil. J Teknol 2016;78:43–7. https://doi.org/10.11113/jt.v78.9051.Search in Google Scholar
16. Adams, RP. Identification of essential oil components by gas chromatography-mass spectrometry. 4th ed. Carol Stream (IL): Allured Publishing Corporation, 2007.Search in Google Scholar
17. Salleh, WMNHW, Ahmad, F, Khong, HY, Zulkifli, RM. Essential oil composition of Malaysian Lauraceae: A mini review. Pharm Sci 2016;22:60–7. https://doi.org/10.15171/ps.2016.11.Search in Google Scholar
18. Salleh, WMNHW, Ahmad, F, Khong, HY. Chemical compositions and antimicrobial activity of the essential oils of Piper abbreviatum, P. erecticaule and P. lanatum (Piperaceae). Nat Prod Commun 2014;9:1795–8. https://doi.org/10.1177/1934578x1400901235.Search in Google Scholar
19. Dai, DN, Huong, LT, Hung, NH, Thang, TD, Ogunwande, IA. Chemical compositions of essential oils of selected medicinal plants from thùa thiên-hu province. Vietnam. J Herbs Spices Med Pl 2014;20:269–81. https://doi.org/10.1080/10496475.2013.865007.Search in Google Scholar
20. Nyegue, M, Amvam-Zollo, PH, Etoa, FX, Agnaniet, H, Chantal, M. Chemical and biological investigations of essential oils from stem barks of Enantia chlorantha Oliv. and Polyalthia suaveolens Engler. & Diels. from Cameroon. Nat Prod Commun 2008;3:1089–96. https://doi.org/10.1177/1934578x0800300711.Search in Google Scholar
21. Brophy, JJ, Goldsack, RJ, Forster, PI. Leaf oils of the Australian species of Polyalthia (Annonaceae). J Essent Oil Res 2001;13:5–7. https://doi.org/10.1080/10412905.2001.9699587.Search in Google Scholar
22. Ogunbinu, AO, Ogunwande, IA, Essien, E, Cioni, PL, Flamini, G. Sesquiterpenes-rich essential oils of Polyalthia longifolia Thw. (Annonaceae) from Nigeria. J Essent Oil Res 2007;19:419–21. https://doi.org/10.1080/10412905.2007.9699941.Search in Google Scholar
23. Cravo, L, Périneau, F, Delmas, M, Bessière, JM. Chemical composition of the fruit and leaf oil of Polyalthia suaveolens Engl. et Diels. J Essent Oil Res 1991;3:459–61. https://doi.org/10.1080/10412905.1991.9697987.Search in Google Scholar
24. Subki, SYM, Jamal, JA, Husain, K, Manshoor, N. Characterisation of leaf essential oils of three Cinnamomum species from Malaysia by gas chromatography and multivariate data analysis. Pharmacogn J 2013;5:22–9. https://doi.org/10.1016/j.phcgj.2012.12.004.Search in Google Scholar
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